Synthesis, antimicrobial evaluation and docking studies of fluorinated imine linked 1,2,3-triazoles

A diverse series of imine linked 1,2,3-triazole hybrids has been synthesized via Cu(I)-promoted click reaction, with an aim to develop some new antimicrobial molecules. The structural characterization the triazole was accomplished using various spectral techniques like 1H NMR, 13C FTIR and HRMS. Among hybrids, 7d exhibited highest efficacy against R. oryzae S. aureus MIC 0.0123 µmol/mL 0.0061 µmol/mL, respectively. Docking studies terminal alkynes (4a, 4b) (6a, 6d, 7c, 7g) showing high potency towards E. coli DNA gyrase C. albicans sterol 14-? demethylase were also undertaken understand binding behaviour.